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Necrotic enteritis is an important disease of poultry that causes economic loss to the broiler industry. Clostridium perfringens is an important bacterium that is responsible for causing necrotic enteritis. Antibiotics are mainly used to control C. perfringens but due to resistance antibiotics are banned in many countries like Canada, Hong Kong, and the European Union. Many alternatives such as probiotics, essential oils, and postbiotics have been developed to control C. perfringens. Among them, probiotics are very important because they can increase beneficial bacteria in the intestine, create a competitive environment in the gut region, and prevent the adhesion and colonization of pathogenic bacteria such as C. perfringens. Probiotics cause immune system modulation, reducing inflammatory markers such as cytokines. Lactobacillus based probiotics also cause weight gain, improve feed conversion ratio, and decrease mortality in poultry which in turn increase profit margin. Several studies have reported that when poultry populations were challenged with C. perfringens then these probiotics prevented intestinal lesions, provided anti-inflammatory effects to the intestine, prevented damage to the villi, and did not allow C. perfringens to form its colony in the intestine. The main aim of this review paper is to explain the updated information on necrotic enteritis, the damages caused to the gut, and the mechanism of actions through which Lactobacilli work against C. perfringens.